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KMID : 0438219790160010317
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Korea University Medical Journal
1979 Volume.16 No. 1 p.317 ~ p.324
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Modified Neuroleptanesthesia with Haloperidol-Morphine-N₂O-O₂
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Abstract
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To obtain stable vital signs and unconsciousness during operation and rapid recovery from anesthesia, neuroleptanesthesia was performed with laloperidol in place of droperidol and morphine in place of fentanyl. We selected randomly 30 patients who had physically status 1 or 11 by the American Society of Anesthesiologist classification and the operating time was expectedly taken more than 2 hours. Then we observed blood pressure, pulse rate, electrocardiographic change, tidal volume, plasma CO2 combing power, post operative pain control, post operative nausea and vomiting. We classified into 2 groups.
In group 1 haloperidol and morphine were -injected 10-15mg intravenously individually. In group 11 haloperidol was injected 5-7.5mg and morphine 10-15mg intravenously.
The following results were obtained.
1) In both groups, induction doses of morphine ranged from 0.17 to 0.28mg, kg and of haloperidol 0.18 to 0.28mg/kg in group 1 and 0.08 to 0.16mg/kg in group 11.
Additional doses of morphine ranged from 2.37 to 5.27mg and 50 minutes after induction were administrated.
2) In both groups, blood pressure and pulse rate were almost stable.
3) We observed arrythmia during induction on lead 11 by means of continous electrocardiographic monitoring. Among 24 patients, 3 cases cleveloped arrythmia. But it was not clear that arrythima was induced from haloperidol and morphine or not.
4) In every case, neostigmine and atropine were administrated from reversal of relaxants but antagnnist was not used for morphine In both groups, tidal volume and plasma bicarbonate ion were not showed clinically significant changes.
5) In both groups, it was not great that difference of time and the number of cases that analgesics were administrated after operation.
6) Post operative nauea and vomiting were not found in group I , but nausea and vomiting occured 2 cases each in group 11.
7) Extapyramidal sign was not noted in both groups. Therefore we expect that the above mentioned drugs become clinically and socioeconomically applied to our country because respiratory and cardiovascurlar system were stable and few complication was noted.
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